Speaking to the European Parliament's Committee on Economic and Monetary Affairs, he was asked about a Financial Times interview in which he warned of the costs of a eurozone break-up.
But he said he believed in the currency's "permanence".
He also warned that 2012 would be a difficult year for banks.
Mr Draghi had told the FT that countries that left the eurozone would create "a big inflation" and would find themselves in "a much weaker position".
The newspaper compared his comments with the rhetoric of his predecessor, Jean-Claude Trichet, who had dismissed a break-up of the eurozone as "absurd".
